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Real members of MyEndometriosisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Dose Luperon Depto Get Worse Every Time You Get The Shot?

A MyEndometriosisTeam Member asked a question 💭
Fairbanks, AK

So far I have had 3 1 month shots and each month my symptoms are worse. I have bad hot flashes and I am also on progesterone tablets.

December 2, 2015
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A MyEndometriosisTeam Member

I had the 3 month shot. The first time was the worst. The second and third times not as bad.

December 10, 2023
A MyEndometriosisTeam Member

The hot flashes I had on Lupron were severe compared the ones I have now: post- hysterectomy/ ovaries removed. I compare it to having Pitocin that causes labor artificially and makes the contractions come fast and hard. The symptom that was the worse for me was the depression I had while on the Lupron.

December 4, 2015
A MyEndometriosisTeam Member

For me I don't have pain because I have progesterone as well as the luperon depot. But I notice my hot flashes are worse now. I am on my treatment for a year because of my stage 4 endometriosis.

December 3, 2015
A MyEndometriosisTeam Member

Unfortunately Lurpon did not help my stage 4 recto-vaginal endo at all. I was still in terrible pain. It was definitely the worst medication I have ever tried. It should also only be used for a short amount of time. Not longer than 6 months.

I had my shot in March this year 11.75mg, and still have hotflushes and night sweats.

Sending you hugs xxx

December 3, 2015
A MyEndometriosisTeam Member

I’m so sorry to hear it hasn’t gotten any better and that you’re going through this.

February 8

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