Answer Summary

Members overwhelmingly cautioned against using Lupron for endometriosis, sharing that it caused significant weight gain, severe brain fog,... Read more

Members overwhelmingly cautioned against using Lupron for endometriosis, sharing that it caused significant weight gain, severe brain fog, nausea, mood swings, hot flashes, and lasting side effects like osteopenia, fatty liver, and nerve damage, with most reporting little to no relief from endometriosis pain. Several members described the medication as forcing them into medical menopause without providing the promised benefits, with some experiencing cognitive and physical effects that persisted for months or even years after stopping the drug. A recurring theme was regret over trying the medication and strong encouragement to explore alternative treatments such as bioidentical progesterone, Visanne, or natural management strategies instead of GnRH agonists.